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Thomas R Shearer Selected Research

N- (4- fluorophenylsulfonyl)- L- valyl- L- leucinal

12/2005Calpain may contribute to hereditary cataract formation in sheep.
7/2005Proteolysis of neuronal cytoskeletal proteins by calpain contributes to rat retinal cell death induced by hypoxia.
2/2002Involvement of calpain in hypoxia-induced damage in rat retina in vitro.

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Thomas R Shearer Research Topics

Disease

13Cataract (Cataracts)
03/2015 - 01/2002
10Hypoxia (Hypoxemia)
11/2020 - 02/2002
4Dry Eye Syndromes (Dry Eye Syndrome)
07/2014 - 02/2007
3Autolysis
11/2020 - 07/2005
3Ganglion Cysts (Ganglion)
01/2020 - 01/2013
3Retinal Degeneration
03/2007 - 10/2004
3Glaucoma
12/2006 - 07/2005
3Ischemia
12/2006 - 02/2002
2Retinal Diseases
11/2020 - 01/2017
2Ocular Hypertension (Glaucoma, Suspect)
06/2014 - 05/2006
2Macular Degeneration (Age-Related Maculopathy)
11/2013 - 10/2009
1Fuchs' Endothelial Dystrophy
11/2016
1Corneal Diseases (Corneal Disease)
08/2015
1Wounds and Injuries (Trauma)
08/2015
1Uveitis
03/2015
1Choroidal Neovascularization
01/2014
1Conjunctivitis
08/2013
1Allergic Conjunctivitis (Giant Papillary Conjunctivitis)
08/2013
1Inflammation (Inflammations)
04/2013
1Necrosis
10/2011
1Diabetic Retinopathy (Retinopathy, Diabetic)
09/2011
1Pathologic Neovascularization
10/2009
1Retinitis Pigmentosa (Pigmentary Retinopathy)
03/2007
1Blindness (Hysterical Blindness)
12/2006
1Miosis
04/2005

Drug/Important Bio-Agent (IBA)

16CalpainIBA
11/2020 - 02/2002
11Retinaldehyde (Retinal)IBA
11/2020 - 02/2002
9SpectrinIBA
09/2015 - 02/2002
8calpain inhibitorsIBA
09/2015 - 02/2002
8Crystallins (Crystallin)IBA
03/2015 - 01/2002
7Peptide Hydrolases (Proteases)FDA Link
11/2020 - 05/2002
7CalciumIBA
10/2011 - 11/2002
5((1S)- 1- ((((1S)- 1- benzyl- 3- cyclopropylamino- 2,3- di- oxopropyl)amino)carbonyl)- 3- methylbutyl)carbamic acid 5-methoxy-3-oxapentyl esterIBA
11/2020 - 03/2007
4Pharmaceutical PreparationsIBA
11/2016 - 04/2005
3CaspasesIBA
11/2020 - 09/2011
3Ophthalmic Solutions (Eye Drops)IBA
01/2017 - 12/2005
3Proteins (Proteins, Gene)FDA Link
04/2013 - 05/2002
3N- (4- fluorophenylsulfonyl)- L- valyl- L- leucinalIBA
12/2005 - 02/2002
2Caspase 3 (Caspase-3)IBA
11/2020 - 09/2011
2Cytoskeletal ProteinsIBA
07/2014 - 07/2005
2Glucose (Dextrose)FDA LinkGeneric
07/2005 - 11/2002
2Protein Isoforms (Isoforms)IBA
10/2004 - 02/2002
2Selenious Acid (Selenite)IBA
05/2002 - 02/2002
1N- (1- acetylpiperidin- 4- yl)- 4- fluorobenzamideIBA
01/2017
1EnzymesIBA
09/2015
1AS 8IBA
09/2015
1Sodium Hydroxide (Caustic Soda)FDA Link
08/2015
1Galectin 3 (LGALS3)IBA
08/2015
1Heptanol (1 Heptanol)IBA
08/2015
1AntibodiesIBA
03/2015
1LubricantsIBA
07/2014
1hydroxide ionIBA
06/2014
1IntegrinsIBA
01/2014
1Retinal Pigments (Pigments, Visual)IBA
11/2013
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2013
1Aluminum Hydroxide (Algeldrate)FDA Link
08/2013
1Janus Kinase InhibitorsIBA
08/2013
1dinitrophenyl-bovine serum albuminIBA
08/2013
1Immunoglobulin E (IgE)IBA
08/2013
1Conditioned Culture MediaIBA
08/2013
1OvalbuminIBA
08/2013
1Phosphotransferases (Kinase)IBA
08/2013
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
08/2013
14(2'- aminoethyl)amino- 1,8- dimethylimidazo(1,2- a)quinoxalineIBA
08/2013
1CytokinesIBA
04/2013
1Type I Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA
01/2013
1Annexin A5IBA
10/2011
1Fluorescein-5-isothiocyanate (FITC)IBA
10/2011
1ethidium homodimerIBA
10/2011
1Lysine (L-Lysine)FDA Link
12/2009
1Calcium IonophoresIBA
12/2009
1Calcimycin (A23187)IBA
12/2009
1ZincIBA
12/2009
1Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
02/2007
1VimentinIBA
12/2005
1Y-39983IBA
04/2005
1calpain 10IBA
10/2004
1alpha-Crystallins (alpha-Crystallin)IBA
05/2002
1m-calpainIBA
05/2002
1Oxygen (Dioxygen)IBA
02/2002

Therapy/Procedure

6Lenses
03/2015 - 02/2002
2Laser In Situ Keratomileusis (LASIK)
07/2014 - 02/2007
2Slit Lamp
12/2005 - 11/2002
1Intraperitoneal Injections
08/2013
1Surgical Amputation (Amputations)
08/2012
1Therapeutics
10/2009